From MEPIS Documentation Wiki
Skype is a proprietary Voice and Video Chat application that allows users to make telephone calls from their computer to other Skype users free of charge, or to landlines and cell phones for a fee. Additional features include instant messaging, file transfer, short message service, video conferencing and its ability to circumvent firewalls.
The easiest way to download the current version of Skype as a *deb is probably the direct download. Version 188.8.131.52-1 has improved video and works well. Details in the Debian Wiki.
- Stable version of Skype can be installed via Synaptic. The Skype Icon will be in Kmenu >>> Internet.
- Versions newer than what is in Synaptic can be installed, however, 4.0 (available at http://download.skype.com/linux/skype-debian_184.108.40.206-1_i386.deb) is the newest version that can be used on MEPIS 11 (also see debian wiki.)
If you have either no audio in (speakers) or no audio out (microphone), check your Kmix settings. Select all channels and make all the sliders up. Also check the settings in Skype options (CTRL-O) >>> Sound Devices
If skype gives a "Problem with Audio Playback" error when trying to make a call, you likely have some hardware conflict between your sound devices, often caused by a webcam with a microphone. Try Skype with the webcam unplugged. Check the "Sound not working" link below.
You can test your webcam in Skype options (CTRL-O) >>> Video Devices.
If that doesn't work, try